Is ‘location, location, location’ all that matters?

“I’m really lucky that I live in a time when location doesn’t really matter,” said Lindsay O’Brien, one of several Eastern Iowa residents who work for national and international brands from their homes. “It’s amazing that I’m able to do global work from the comfort of my couch in Davenport.”

Ms. O’Brien’s remote work includes designing cover art for the Los Angeles-based singer Julia Michaels and…